Endocrine and Metabolic Disorders

Endocrine and metabolic diseases span a vast range of conditions. Together, they affect many millions of Americans and can profoundly decrease quality of life. NIDDK supports research on many of these conditions, including osteoporosis, cystic fibrosis, hypothyroidism, and obesity. Osteoporosis is a disease marked by reduced bone strength and linked to aging and fracture risk. 53 million people in the United States either have or are at risk for osteoporosis. Hypothyroidism, or underactive thyroid, affects about 4.6 percent of the U.S. population age 12 and older. More than 30,000 Americans have cystic fibrosis, an inherited disease in which salt and water cannot flow appropriately in many critical tissues. Despite dramatic advances in treatment and life expectancy, cystic fibrosis substantially reduces lifespan and its management is challenging.

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